Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial.

 2013 Oct;170(10):1134-42. doi: 10.1176/appi.ajp.2013.13030392.

Murrough JWIosifescu DVChang LCAl Jurdi RKGreen CEPerez AMIqbal SPillemer SFoulkes AShah ACharney DSMathew SJ.

Ketamine, a glutamate N-methyl-d-aspartate (NMDA) receptor antagonist, has shown rapid antidepressant effects, but small study groups and inadequate control conditions in prior studies have precluded a definitive conclusion. The authors evaluated the rapid antidepressant efficacy of ketamine in a large group of patients with treatment-resistant major depression…

Ketamine demonstrated rapid antidepressant effects in an optimized study design, further supporting NMDA receptor modulation as a novel mechanism for accelerated improvement in severe and chronic forms of depression.

The ketamine group had greater improvement in the MADRS (Montgomery-Åsberg Depression Rating Scale) score than the midazolam (placebo) group 24 hours after treatment.

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