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Efficacy of Intravenous Ketamine for Treatment of Chronic Posttraumatic Stress Disorder

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JAMA Psychiatry. June 2014
Adriana Feder, MD1Michael K. Parides, PhD2James W. Murrough, MD1,3et al
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A Randomized Clinical Trial 
Important:  Few pharmacotherapies have demonstrated sufficient efficacy in the treatment of posttraumatic stress disorder (PTSD), a chronic and disabling condition.
Objective:  To test the efficacy and safety of a single intravenous subanesthetic dose of ketamine for the treatment of PTSD and associated depressive symptoms in patients with chronic PTSD.
Conclusions and Relevance:  This study provides the first evidence for rapid reduction in symptom severity following ketamine infusion in patients with chronic PTSD. If replicated, these findings may lead to novel approaches to the pharmacologic treatment of patients with this disabling condition.
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… Symptoms in 7 patients randomly assigned to ketamine first remained significantly reduced after infusion.

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