Efficacy of Ketamine in Bipolar Depression: Systematic Review and Meta-analysis

 2015 Nov;21(6):427-35. doi: 10.1097/PRA.0000000000000106.

Parsaik AK1Singh BKhosh-Chashm DMascarenhas SS.

This study suggests that ketamine is effective in treatment-resistant bipolar depression and may reduce suicidal ideation and anhedonia… The 2 studies that were excluded from the meta-analysis also showed significant improvement in depression after ketamine therapy. Individual studies also reported improvement in anhedonia and suicidal ideation after ketamine therapy. None of the subjects had serious side effects, and the side effects were similar between the ketamine and placebo groups.

The maximum improvement was observed 40 minutes after the ketamine infusion.

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