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Ketamine in Chronic Pain Management: An Evidence-Based Review

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By Hocking, Graham MB, ChB, DMCC, FRCA, FFPMANZCA*†; Cousins, Michael J. MB, BS, MD, FANZCA, FRCA, FFPMANZCA, FAChP (RACP)*
Anesthesia & Analgesia: December 2003
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When first and second-line drugs such as opioids, anticonvulsants, or antidepressants fail to provide satisfactory analgesia for the patient with chronic pain, third-line drugs such as ketamine may provide a suitable option.
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Ketamine reduced both continuous and evoked pain at the expense of only modest side effects.

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