Biol Psychiatry. Author manuscript; available in PMC 2013 Aug 15.
,1,2 ,3 ,1 ,1 ,4 ,5,6,2 ,7,8 ,1,2,9,10 and 1,2
Ketamine is reported to have rapid antidepressant effects, however there is limited understanding of the time-course of ketamine effects beyond a single infusion. A previous report including 10 participants with treatment-resistant major depression (TRD) found that six ketamine infusions resulted in a sustained antidepressant effect. In the current report, we examined the pattern and durability of antidepressant effects of repeated ketamine infusions in larger sample, inclusive of the original.