Safety and Efficacy of Repeated-Dose Intravenous Ketamine for Treatment-Resistant Depression

By Biological Psychiatry, 2010.

Marije aan het Rot, Katherine A. Collins, James W. Murrough, Andrew M. Perez, David L. Reich, Dennis S. Charney, and Sanjay J. Mathew

A single subanesthetic (intravenous) IV dose of ketamine might have rapid but transient antidepressant effects in patients with treatment-resistant depression (TRD). Here we tested the tolerability, safety, and efficacy of repeated-dose open-label IV ketamine (six infusions over 12 days) in 10 medication-free symptomatic patients with TRD who had previously shown a meaningful antidepressant response to a single dose…

Ketamine elicited minimal positive psychotic symptoms. Three patients experienced significant but transient dissociative symptoms. Side effects during and after each ketamine infusion were generally mild.

One patient remained anti-depressant-free with minimal depressive symptoms for 3 months.

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